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BACKGROUND

The ability of gut microbiota to communicate with the brain and thus modulate behavior is emerging as an exciting concept in health and disease. The enteric microbiota interacts with the host to form essential relationships that govern homeostasis. Despite the unique enteric bacterial fingerprint of each individual, there appears to be a certain balance that confers health benefits.

It is, therefore, reasonable to note that a decrease in the desirable gastrointestinal bacteria will lead to deterioration in gastrointestinal, neuro- endocrine or immune relationships and ultimately disease. Therefore, studies focusing on the impact of enteric microbiota on the host and in particular on the central nervous system are essential to our understanding of the influence of this system. The HMP Demonstration Projects, explores if there is a relationship between disease states and changes in the human microbiome, and development of new technological and bioinformatic tools needed.

Publication in the journal Nature, reported the results of the research on Human Microbiome Project (HMP) provides a comprehensive research on normal human microbiome, which is very diverse and abundant microbial species unique in each individual human being. An analysis of microbes in the human gut metagenomic reveals the diversity and how we are interdependent on microbial populations in the gastrointestinal tract. Together with our microbes-bacteria are human superorganism with immense metabolic diversity. Microbiome is the total microbial genetic material (genome), and interactions in a given environment. The term was coined by Joshua Lederberg, who argued that the microorganisms that live in the human body must be included as part of the human genome, because of their influence on human physiology.


Organized by :

ISSPP
Indonesian Scientific Society for Probiotics and Prebiotics